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Uterus Transplantation Clinical Trial

  • First in the United States: Baby Born to Mother Who Received Transplanted Uterus

    This live birth is the latest medical milestone in the uterine transplant clinical trial at Baylor University Medical Center, being conducted through Baylor Scott & White Research Institute.

About the Trial

Baylor University Medical Center Dallas, part of Baylor Scott & White Health, is among the first in the U.S. to explore uterus transplantation, which is being studied as a new infertility treatment option for women with absolute uterine factor infertility (AUI).

As part of this clinical trial, 10 women will receive a donated uterus. After a year of monitoring, each patient may be eligible to have a fertilized egg implanted. The goal of the trial is a healthy pregnancy and a live birth.

Recipient Eligibility

  • Women with AUI
  • Ages 20-35, with working ovaries
  • BMI of less than 30
  • Cancer free for at least 5 years
  • Negative for HIV, hepatitis B and C, chlamydia, gonorrhea and herpes
  • No history of diabetes
  • Non-smoker

Donor Requirements

  • Ages 30-65 (If under 40, must of undergone measures to ensure sterilization.)
  • At least 1 full-term delivery
  • BMI of less than 30
  • Cancer free for last 5 years
  • Negative for HIV, Hepatitis, Gonorrhea/ Chlamydia and Herpes
  • Negative history of Hypertension or Diabetes

Frequently Asked Questions

Yes, a similar trial in Sweden for women with uterine factor infertility resulted in seven womb transplants and five live births. In 2014, a 36-year-old Swedish trial participant became the first woman in the world to give birth to a baby via a donated uterus. The Swedish study took place after more than a decade of lab research that showed promising results for this procedure. The Baylor University Medical Center team will apply the insights of those outcomes to this study, with special input from the researchers involved in the initial effort at Sahlgrenska University Hospital in Gothenburg, Sweden.

After a successful live birth, the recipient may have the option to keep the uterus for a second pregnancy. The physicians will consider the course of the first pregnancy and together with the mother, determine when and how to move forward safely towards a second pregnancy.

Uterine transplantation is not designed as a permanent organ donation. Because carrying foreign body tissue can increase infection risk and requires lifelong anti-rejection medication, women in this study will undergo a hysterectomy after one or two successful pregnancies.

Prior to the surgery, recipients will undergo in-vitro fertilization (IVF), which is possible because qualified patients must have healthy and otherwise normal functioning ovaries. In-vitro fertilization uses reproductive technology to retrieve eggs from the ovaries and fertilize in the lab with sperm from the subject’s male partner. After surgery, the women will be monitored and may be eligible for an embryo produced from the earlier IVF procedures to be transferred as early as a year following the womb transplant. If implantation is successful and the recipient becomes pregnant, she will be routinely monitored until her baby is delivered by cesarean section.

Yes. The entire process of transplantation, fertilization, prenatal care and delivery are all connected as part of this study and will take place at Baylor Dallas.

Frequently Asked Questions

Has this been done before?

Yes, a similar trial in Sweden for women with uterine factor infertility resulted in seven womb transplants and five live births. In 2014, a 36-year-old Swedish trial participant became the first woman in the world to give birth to a baby via a donated uterus. The Swedish study took place after more than a decade of lab research that showed promising results for this procedure. The Baylor University Medical Center team will apply the insights of those outcomes to this study, with special input from the researchers involved in the initial effort at Sahlgrenska University Hospital in Gothenburg, Sweden.


Can a recipient have more than one child with a donated uterus?

After a successful live birth, the recipient may have the option to keep the uterus for a second pregnancy. The physicians will consider the course of the first pregnancy and together with the mother, determine when and how to move forward safely towards a second pregnancy.


Does the donated uterus remain implanted in the recipient after the baby is born?

Uterine transplantation is not designed as a permanent organ donation. Because carrying foreign body tissue can increase infection risk and requires lifelong anti-rejection medication, women in this study will undergo a hysterectomy after one or two successful pregnancies.


What is the process?

Prior to the surgery, recipients will undergo in-vitro fertilization (IVF), which is possible because qualified patients must have healthy and otherwise normal functioning ovaries. In-vitro fertilization uses reproductive technology to retrieve eggs from the ovaries and fertilize in the lab with sperm from the subject’s male partner. After surgery, the women will be monitored and may be eligible for an embryo produced from the earlier IVF procedures to be transferred as early as a year following the womb transplant. If implantation is successful and the recipient becomes pregnant, she will be routinely monitored until her baby is delivered by cesarean section.


Do study participants have to be located in Dallas?

Yes. The entire process of transplantation, fertilization, prenatal care and delivery are all connected as part of this study and will take place at Baylor University Medical Center at Dallas.

Our Medical Team

Giuliano Testa, MD

Principal investigator and chief of abdominal transplant at Baylor University Medical Center

Robert T. Gunby Jr., MD

Medical director of Labor and Delivery and assistant chief of the Department of Obstetrics and Gynecology at Baylor University Medical Center

E. Colin Koon, MD, PhD

Co-chair for robotic surgical services at Baylor University Medical Center

Liza Johannesson, MD, PhD

Obstetrician and gynecologist with a clinical work and research focus on uterus transplantation at Sahlgrenska University Hospital in Sweden

Gregory J. McKenna, MD

Transplant and hepatobiliary surgeon

Tiffany L. Anthony, MD

Transplant surgeon

John M. Putman, MD

Reproductive endocrinology and infertility specialist

Ann Marie Warren, PhD, ABPP-Rp

Licensed clinical psychologist

Kristin Posey Wallis, BSN, RNC

Obstestrics research nurse at Baylor University Medical Center

Publications and Research

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Refer a Patient

Please contact us for more information about the uterus transplantation clinical trial program at Baylor University Medical Center.

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